解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Monocytes are effectors of the inflammatory response to microbes. Human CD14(+) monocytes specialize in phagocytosis and production of reactive oxygen species and secrete inflammatory cytokines in response to a broad range of microbial cues. Here, we have characterized the functions of human monocytes that lack CD14 (...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2010.08.012
更新日期:2010-09-24 00:00:00
abstract::In this issue of Immunity, Pérez de Diego et al. (2010) report a primary human immune deficiency involving a TRAF protein and show that human immunity to the virus HSV-1 is critically dependent on TRAF3. ...
journal_title:Immunity
pub_type: 评论,杂志文章
doi:10.1016/j.immuni.2010.09.008
更新日期:2010-09-24 00:00:00
abstract::A large and diverse array of chemoattractants control leukocyte trafficking, but how these apparently redundant signals collaborate in vivo is still largely unknown. We previously demonstrated an absolute requirement for the lipid chemoattractant leukotriene B(4) (LTB(4)) and its receptor BLT1 for neutrophil recruitme...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2010.07.018
更新日期:2010-08-27 00:00:00
abstract::Mutations in the IL23R gene are linked to inflammatory bowel disease susceptibility. Experimental models have shown that interleukin-23 (IL-23) orchestrates innate and T cell-dependent colitis; however, the cell populations it acts on to induce intestinal immune pathology are unknown. Here, using Il23r(-/-) T cells, w...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2010.08.010
更新日期:2010-08-27 00:00:00
abstract::Transcriptional regulation of the Nos2 gene encoding inducible nitric oxide synthase (iNOS) requires type I interferon (IFN-I) signaling and additional signals emanating from pattern recognition receptors. Here we showed sequential and cooperative contributions of the transcription factors ISGF3 (a complex containing ...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2010.07.001
更新日期:2010-07-23 00:00:00
abstract::The chemokine sink hypothesis pertaining to erythrocyte Duffy Antigen Receptor for Chemokines (DARC) during inflammation has received considerable attention, but lacks direct in vivo evidence. Here we demonstrate, using mice with a targeted deletion in CXCL5, that CXCL5 bound erythrocyte DARC and impaired its chemokin...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2010.07.009
更新日期:2010-07-23 00:00:00
abstract::Natural hosts for simian immunodeficiency virus (SIV) can be, and are often naturally, infected with species-specific SIVs, but do not develop acquired immunodeficiency syndrome (AIDS). These natural hosts maintain high SIV viral loads, but avoid immunodeficiency. Elucidating the mechanisms that allow natural hosts to...
journal_title:Immunity
pub_type: 杂志文章,评审
doi:10.1016/j.immuni.2010.06.004
更新日期:2010-06-25 00:00:00
abstract::Phenotypic plasticity of T helper 17 (Th17) cells suggests instability of chromatin structure of key genes of this lineage. We identified epigenetic modifications across the clustered Il17a and Il17f and the Ifng loci before and after differential IL-12 or TGF-beta cytokine signaling, which induce divergent fates of T...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2010.04.016
更新日期:2010-05-28 00:00:00
abstract::T cell activation is tightly regulated to avoid autoimmunity. Gene related to anergy in lymphocytes (GRAIL, encoded by Rnf128) is an E3 ubiquitin ligase associated with T cell tolerance. Here, we generated and analyzed GRAIL-deficient mice and found they were resistant to immune tolerance induction and exhibited great...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2010.05.002
更新日期:2010-05-28 00:00:00
abstract::The concept of an alternative pathway of macrophage activation has stimulated interest in its definition, mechanism, and functional significance in homeostasis and disease. We assess recent research in this field, argue for a restricted definition, and explore pathways by which the T helper 2 (Th2) cell cytokines inte...
journal_title:Immunity
pub_type: 杂志文章,评审
doi:10.1016/j.immuni.2010.05.007
更新日期:2010-05-28 00:00:00
abstract::The transcription factor GATA3 is crucial for the differentiation of naive CD4(+) T cells into T helper 2 (Th2) cells. Here, we show that deletion of Gata3 allowed the appearance of interferon-gamma (IFN-gamma)-producing cells in the absence of interleukin-12 (IL-12) and IFN-gamma. Such IFN-gamma production was transc...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2010.04.004
更新日期:2010-04-23 00:00:00
abstract::T helper cell differentiation is controlled by a network of transcription factors. In this issue of Immunity, Yagi et al. (2010) describe the opposing effects of transcription factors Runx3 and GATA3 in the network promoting T helper 1 cell development. ...
journal_title:Immunity
pub_type: 评论,杂志文章
doi:10.1016/j.immuni.2010.04.006
更新日期:2010-04-23 00:00:00
abstract::Genetic studies and other experimental data have linked inflammatory bowel diseases with inflammasome activation. In this issue of Immunity, Zaki et al. (2010) and Dupaul-Chicoine et al. (2010) provide a detailed characterization of the regulatory task of the inflammasome in intestinal epithelial cells. ...
journal_title:Immunity
pub_type: 评论,杂志文章
doi:10.1016/j.immuni.2010.03.010
更新日期:2010-03-26 00:00:00
abstract::CD4(+) T cells deficient in signaling lymphocyte activation molecule (SLAM)-associated protein (SAP) exhibit a selective impairment in adhesion to antigen-presenting B cells but not dendritic cells (DCs), resulting in defective germinal center formation. However, the nature of this selective adhesion defect remained u...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2010.01.010
更新日期:2010-02-26 00:00:00
abstract::Understanding heterogeneity in adaptive immune responses is essential to dissect pathways of memory B and T cell differentiation and to define correlates of protective immunity. Traditionally, immunologists have deconvoluted this heterogeneity with flow cytometry--with combinations of markers to define signatures that...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2010.02.001
更新日期:2010-02-26 00:00:00
abstract::The mechanisms underpinning integration of instructions that program naive CD8+ T cells for effector and/or memory differentiation are not well understood. Herein, we demonstrate that interleukin-12 (IL-12) enhanced and sustained antigen and costimulatory molecule (B7.1)-induced mTOR kinase activity in naive CD8+ (OT-...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2009.10.010
更新日期:2010-01-29 00:00:00
abstract::Regulatory T (Treg) cells are essential for maintaining immune homeostasis. Although Foxp3 expression marks the commitment of progenitors to Treg cell lineage, how Treg cells are generated during lymphocyte development remains enigmatic. We report here that the c-Rel transcription factor controlled development of Treg...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2009.10.006
更新日期:2009-12-18 00:00:00
abstract::In this issue of Immunity, Turtle et al. (2009) describe the identification of a distinct CD8(+) memory T cell subset in humans, which could bring us closer to the identification of the enigmatic "memory stem cell." ...
journal_title:Immunity
pub_type: 评论,杂志文章
doi:10.1016/j.immuni.2009.10.002
更新日期:2009-11-20 00:00:00
abstract::Immunotherapy, especially therapeutic vaccination, has a great deal of potential in the treatment of cancer and certain infectious diseases such as HIV (Allison et al., 2006; Fauci et al., 2008; Feldmann and Steinman, 2005). Numerous vaccine candidates have been tested in patients with a variety of tumor types and chr...
journal_title:Immunity
pub_type: 信件
doi:10.1016/j.immuni.2009.09.007
更新日期:2009-10-16 00:00:00
abstract::T helper 17 (Th17) cells play major roles in autoimmunity and bacterial infections, yet how T cell receptor (TCR) signaling affects Th17 cell differentiation is relatively unknown. We demonstrate that CD4(+) T cells lacking Itk, a tyrosine kinase required for full TCR-induced phospholipase C-gamma (PLC-gamma1) activat...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2009.07.009
更新日期:2009-10-16 00:00:00
abstract::The mammalian intestinal mucosal surface is continuously exposed to a complex and dynamic community of microorganisms. These microbes establish symbiotic relationships with their hosts, making important contributions to metabolism and digestive efficiency. The intestinal epithelial surface is the primary interface bet...
journal_title:Immunity
pub_type: 杂志文章,评审
doi:10.1016/j.immuni.2009.08.009
更新日期:2009-09-18 00:00:00
abstract::The investigation of gammadelta T cells has identified a rapid lymphoid stress-surveillance response to microbial and nonmicrobial tissue perturbation. In addition to providing local protection, this response provides an immediate source of cytokines, chemokines, and other functions that can substantially affect downs...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2009.08.006
更新日期:2009-08-21 00:00:00
abstract::Despite compromised T cell antigen receptor (TCR) signaling, mice in which tyrosine 136 of the adaptor linker for activation of T cells (LAT) was constitutively mutated (Lat(Y136F) mice) accumulate CD4(+) T cells that trigger autoimmunity and inflammation. Here we show that equipping postthymic CD4(+) T cells with LAT...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2009.05.013
更新日期:2009-08-21 00:00:00
abstract::Blood, lymphoid tissues, and placenta contain diverse subpopulations of natural killer (NK) cells that possess distinct immune functions. Recent studies have shown that human and mouse gut-associated lymphoid tissues harbor a unique NK cell subset that specializes in production of interleukin (IL)-22. This cytokine pl...
journal_title:Immunity
pub_type: 杂志文章,评审
doi:10.1016/j.immuni.2009.06.008
更新日期:2009-07-17 00:00:00
abstract::CD1d-restricted natural killer T cells (NKT cells) possess a wide range of effector and regulatory activities that are related to their ability to secrete both T helper 1 (Th1) cell- and Th2 cell-type cytokines. We analyzed presentation of NKT cell activating alpha galactosylceramide (alphaGalCer) analogs that give pr...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2009.03.022
更新日期:2009-06-19 00:00:00
abstract::NLRP3 nucleates the inflammasome, a protein complex responsible for cleavage of prointerleukin-1beta (IL-1beta) to its active form. Mutations in the NLRP3 gene cause the autoinflammatory disease spectrum cryopyrin-associated periodic syndromes (CAPS). The central role of IL-1beta in CAPS is supported by the response t...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2009.05.005
更新日期:2009-06-19 00:00:00
abstract::Memory lymphocytes are characterized by their ability to exhibit a rapid response to the recall antigen, in which differential transcription is important, yet the underlying mechanism is not understood. We report here a genome-wide analysis of histone methylation on two histone H3 lysine residues (H3K4me3 and H3K27me3...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2009.05.006
更新日期:2009-06-19 00:00:00
abstract::Perforation of membranes and pore formation is mediated by polymerization of proteins of the immune system, complement C9 and Perforin, which share the conserved MACPF domain. In this issue of Immunity, Baran et al. (2009) identify the molecular mechanism initiating polymerization as charge interactions in the MACPF d...
journal_title:Immunity
pub_type: 评论,杂志文章
doi:10.1016/j.immuni.2009.04.004
更新日期:2009-05-01 00:00:00
abstract::A unique subpopulation of spleen dendritic cells (DCs) that express the CD8 surface marker efficiently present phagocytosed antigens to CD8(+) T lymphocytes in a process called "crosspresentation," which initiates cytotoxic immune responses. We now show that the small GTPase Rac2 plays a critical role in antigen cross...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2009.01.013
更新日期:2009-04-17 00:00:00
abstract::The nucleotide-binding domain and leucine-rich-repeat-containing (NLR) family of pattern-recognition molecules mediate host immunity to various pathogenic stimuli. However, in vivo evidence for the involvement of NLR proteins in viral sensing has not been widely investigated and remains controversial. As a test of the...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2009.02.005
更新日期:2009-04-17 00:00:00
abstract::To determine the site and mechanism of suppression by regulatory T (Treg) cells, we investigated their migration and function in an islet allograft model. Treg cells first migrated from blood to the inflamed allograft where they were essential for the suppression of alloimmunity. This process was dependent on the chem...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2008.12.022
更新日期:2009-03-20 00:00:00
abstract::Immunity to the intestinal parasite Heligomosomoides polygyrus is dependent on the successful generation of T helper 2 (Th2) memory cells. We showed that B cells contribute to immunity against H. polygyrus by producing antibody (Ab) and by promoting expansion and differentiation of primary and memory Th2 cells. We als...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2009.01.006
更新日期:2009-03-20 00:00:00
abstract::The Notch2 ligand DL1 is required for marginal zone B cell development. In this issue of Immunity, Tan et al. (2009) show that modification of Notch2 by Fringe enzymes is critical to maturing B cells for accessing DL1 on vascular endothelial cells. ...
journal_title:Immunity
pub_type: 评论,杂志文章
doi:10.1016/j.immuni.2009.01.003
更新日期:2009-02-20 00:00:00
abstract::In this issue of Immunity, Conche et al. (2009) define an antigen-independent signaling pathway that is dependent on cyclic adenosine monophosphate and extracellular signal-regulated kinase and T cells for subsequent T cell antigen receptor signaling. ...
journal_title:Immunity
pub_type: 评论,杂志文章
doi:10.1016/j.immuni.2008.12.007
更新日期:2009-01-16 00:00:00
abstract::Multipotential naive CD4(+) T cells differentiate into distinct lineages including T helper 1 (Th1), Th2, Th17, and inducible T regulatory (iTreg) cells. The remarkable diversity of CD4(+) T cells begs the question whether the observed changes reflect terminal differentiation with heritable epigenetic modifications or...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2008.12.009
更新日期:2009-01-16 00:00:00
abstract::Precise intrathymic cell migration is important for thymocyte maturation and organ architecture. The orchestration of thymocyte trafficking, however, is not well understood at a molecular level. Here, we described highly regulated plexinD1 expression on CD4+CD8+ double positive (DP) thymocytes. PlexinD1 expression was...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2008.10.008
更新日期:2008-12-19 00:00:00
abstract::Differentiation of memory cells involves DNA-sequence changes in B lymphocytes but is less clearly defined in T cells. RNA rearrangement is identified here as a key event in memory T cell differentiation by analysis of a mouse mutation that altered the proportions of naive and memory T cells and crippled the process o...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2008.11.004
更新日期:2008-12-19 00:00:00
abstract::Uric acid (UA) crystals are a potent stimulator of inflammation, but how they activate immune cells is not known. In this issue of Immunity, Ng et al. (2008) provide evidence suggesting that UA activates the Syk kinase via membrane cholesterol. ...
journal_title:Immunity
pub_type: 评论,杂志文章
doi:10.1016/j.immuni.2008.10.005
更新日期:2008-11-14 00:00:00
abstract::Dendritic cells (DCs) are the antigen presenting cells that initiate and regulate immunity. By studying these cells in vivo, we will be able to move beyond standard approaches and design vaccines that directly harness the elaborate properties of DCs to control immunity. ...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2008.08.001
更新日期:2008-09-19 00:00:00
abstract::The thymic medulla provides a microenvironment where medullary thymic epithelial cells (mTECs) express autoimmune regulator and diverse tissue-restricted genes, contributing to launching self-tolerance. Positive selection is essential for thymic medulla formation via a previously unknown mechanism. Here we show that t...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2008.06.018
更新日期:2008-09-19 00:00:00